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Smiles: NC1=CC2=C(NCCC3C=CC(=CC=3)OC3C=CC=CC=3)N=CN=C2C=C1
InChiKey: WIJZXSAJMHAVGX-DHLKQENFSA-N
It has Gram-negative coverage which includes Pseudomonas aeruginosa but limited Gram-positive coverage
CAS Number: 157716-52-4
GDC-0032 Size:Solid 2 mg Smiles: NC1=CC2=C(NCCC3C=CC(=CC=3)OC3C=CC=CC=3)N=CN=C2C=C1Taselisib, also known as GDC0032 or RG7606, is a selective, potent, orally bioavailable inhibitor of PI3Ka with a Ki = 0. 2nM, and with reduced inhibitory activity against PI3K. This selectivity profile, and excellent pharmacokinetic and pharmaceutical properties, allowed for greater efficacy in vivo at the maximum tolerated dose relative to a pan Class I PI3K inhibitor in PIK3CA mutant xenografts. Notably, GDC 0032 preferentially inhibited PIK3CA
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