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[Boceprevir (Victrelis)
a novel transforming growth factor beta receptor type I and type II dual inhibitor
Molecular Weight: 362
CAS Number: 1884220-36-3
LGK974 - Porcupine (Wnt) Inhibitor. CAS# 1243244-14-5 Catalog No.:M60106-C [Boceprevir (Victrelis)LGK974, CAS No. 1243244 14 5, is a highly potent, selective and orally bioavailable Porcupine inhibitor (Wnt signaling antagonist) with an IC50 ~0. 4 nM. LGK974 potently inhibits Wnt signaling in vitro and in vivo, including reduction of the Wnt dependent LRP6 phosphorylation and the expression of Wnt target genes, such as AXIN2. LGK974 is potent and efficacious in multiple tumor models at well tolerated doses in vivo, including murine and rat
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